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Transcranial Ultrasound in Clinical Sonothrombolysis (TUCSON) Trial Ann Neurol 66:28-38, Molina,C.A.,et al, 2009 See this aricle in Pubmed Article Abstract Perflutren lipid uS can be safely combined with systemic tPA and ultrasound at a dose of 1.4 ml. Safety concerns in the second dose tier may necessitate extended enrollment and further experiments to determine the mechanisms by which microspheres interact with tissues. In both dose tiers, sonothrombolysis with uS and tPA shows a trend toward higher early recanalization and clinical recovery rates compared to standard intravenous tPA therapy.

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